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Omtrent seven-9 % af den kaukasiske befolkning har variationer i CYP2D6 genet som koder for ingen- eller nedsat aktivitet af CYP2D6 (se personlig medicin ). Tramadol et produg der omdannes til den aktive metabolit through CYP2D6. Patienter med nedsat eller manglende aktivitet af CYP2D6, vil have reduceret- eller manglende effekt af tramadol.Still,

"Over the nineteen nineties There was decreased funding in this field [medications] and at the same time There's been an increase in the availability of medicine with a corresponding boost in life time prevalence of drug use among the youngsters.“I’ve experienced only optimistic effects on my overall body and I've my bloodwork to confirm it.”

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